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Article

Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tube.

The Journal of pathology - 1 Sept 2010

Chen Eleanor Y, Mehra Karishma, Mehrad Mitra, Ning Gang, Miron Alexander, Mutter George L, Monte Nicholas, Quade Bradley J, McKeon Frank D, Yassin Yosuf, Xian Wa, Crum Christopher P

Abstract excerpt

The 'p53 signature' is a benign secretory cell outgrowth in the distal Fallopian tube that shares properties with ovarian serous cancer-including p53 mutations-and is a putative serous cancer precursor. We expanded the precursor definition to all secretory cell outgrowths (SCOUTs) of 30 or more cells and scored normal (N) and altered (A) expression of both p53 and PAX2, a gene down-regulated in ovarian and...

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Share to Cell Transformation, Neoplastic
Share to Cystadenocarcinoma, Serous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fallopian Tube Neoplasms

Share to PAX2 gene

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Share to Neoplasm Proteins

Share to PAX2 Transcription Factor

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 20597068
DOI: 10.1002/path.2739
PMCID: PMC2914810

Genes

PAX2
BCL2
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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