Article
Genetic and immunohistochemical studies identify recurrent ACTB mutations and PTEN alterations in tubular adenomas of the breast.
Histopathology - 1 May 2026
Ingyin Hnin, Solomon James P, Li Yuewei, Xu Dong, Racchumi Joelle, Wang Aihui, Allard Grace, Gao Guofeng, Ma Zhicheng, Lin Chieh-Yu, Chen Yunn-Yi, Krings Gregor, Troxell Megan L, Hoda Syed A, Bean Gregory R, Boyraz Baris
Abstract excerpt
AIMS: Tubular adenoma of the breast (TAB) is a rare and understudied neoplasm, initially thought to represent a fibroadenoma (FA) variant. Recently, it has been shown that TABs lack MED12 mutations indicating a distinct pathogenesis, and an association between multiple TABs and Cowden syndrome (CS) has been described. We sought to evaluate PTEN status in TABs with immunohistochemistry (IHC) and identify other...
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