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Prevalence and Independence of p53 Signatures and β-Catenin Signatures in Risk-Reducing Salpingo-Oophorectomy Specimens.

Pathology international - 1 Jul 2026

Koyama Kei, Tsukita Hikaru, Ishinari Takahiro, Takahashi Ayana, Miyabe Ken, Yoshida Makoto, Kudo-Asabe Yukitsugu, Nanjo Hiroshi, Waga Masato, Kaneko Enami, Hirakawa Takeo, Sugawara Tae, Makino Kenichi, Terada Yukihiro, Goto Akiteru

Abstract excerpt

Clusters of epithelial cells of the fallopian tube exhibiting aberrant p53 expression, termed "p53 signatures," are detected at a relatively high frequency and have been regarded as putative precursors of high-grade serous carcinoma (HGSC). In contrast, the recently proposed "β-catenin signature" represents a distinct tubal epithelial alteration characterized by the aberrant expression of β-catenin, the...

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Identifiers

PMID: 42482410
DOI: 10.1111/pin.70152
PMCID: PMC13389328

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BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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