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Article

DNA damage regulation and its role in drug-related phenotypes in the malaria parasites.

Scientific reports - 1 Apr 2016

Gupta Devendra Kumar, Patra Alok Tanala, Zhu Lei, Gupta Archana Patkar, Bozdech Zbynek

Abstract excerpt

DNA of malaria parasites, Plasmodium falciparum, is subjected to extraordinary high levels of genotoxic insults during its complex life cycle within both the mosquito and human host. Accordingly, most of the components of DNA repair machinery are conserved in the parasite genome. Here, we investigated the genome-wide responses of P. falciparum to DNA damaging agents and provided transcriptional evidence of the...

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Identifiers

PMID: 27033103
DOI: 10.1038/srep23603
PMCID: PMC4817041

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