Prevalence of APC and PTEN Alterations in Urachal Cancer.

doi:10.1007/s12253-020-00872-6

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Article

Prevalence of APC and PTEN Alterations in Urachal Cancer.

Pathology oncology research : POR - 1 Oct 2020

Nagy Nikolett, Reis Henning, Hadaschik Boris, Niedworok Christian, Módos Orsolya, Szendrői Attila, Bíró Krisztina, Hager Thomas, Herold Thomas, Ablat Jason, Black Peter C, Okon Krzysztof, Tolkach Yuri, Csizmarik Anita, Oláh Csilla, Keresztes David, Bremmer Felix, Gaisa Nadine T, Kriegsmann Joerg, Kovalszky Ilona, Kiss András, Tímár József, Szász Marcell A, Rink Michael, Fisch Margit, Nyirády Péter, Szarvas Tibor

Abstract excerpt

Urachal carcinoma (UrC) is a rare tumor with remarkable histological and molecular similarities to colorectal cancer (CRC). Adenomatous polyposis coli (APC) is the most frequently affected gene in CRC, but the prevalence and significance of its alterations in UrC is poorly understood. In addition, loss of phosphatase and tensin homologue (PTEN) was shown to be associated with therapy resistance in CRC. Our...

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PMID: 32754865
DOI: 10.1007/s12253-020-00872-6
PMCID: PMC7471184

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