Article
Mutations of KRAS, NRAS, BRAF, EGFR, and PIK3CA genes in urachal carcinoma: Occurence and prognostic significance.
Oncotarget - 28 Jun 2016
Módos Orsolya, Reis Henning, Niedworok Christian, Rübben Herbert, Szendröi Attila, Szász Marcell A, Tímár József, Baghy Kornélia, Kovalszky Ilona, Golabek Tomasz, Chlosta Piotr, Okon Krzysztof, Peyronnet Benoit, Mathieu Romain, Shariat Shahrokh F, Hollósi Péter, Nyirády Péter, Szarvas Tibor
Abstract excerpt
PURPOSE: Targeted therapy represents an attractive alternative for rare tumors such as urachal carcinoma (UrC). The aim of this study was to assess the mutations of the most commonly affected 5 genes in the targetable EGFR-pathway in UrC and comapre their frequencies to those of found in urothelial and colorectal cancer. MATERIALS AND METHODS: Mutational hot-spots of selected genes were tested in 22 UrC samples...
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