Article
Pathogenic and targetable genetic alterations in 70 urachal adenocarcinomas.
International journal of cancer - 1 Oct 2018
Reis Henning, van der Vos Kristan E, Niedworok Christian, Herold Thomas, Módos Orsolya, Szendrői Attila, Hager Thomas, Ingenwerth Marc, Vis Daniël J, Behrendt Mark A, de Jong Jeroen, van der Heijden Michiel S, Peyronnet Benoit, Mathieu Romain, Wiesweg Marcel, Ablat Jason, Okon Krzysztof, Tolkach Yuri, Keresztes David, Nagy Nikolett, Bremmer Felix, Gaisa Nadine T, Chlosta Piotr, Kriegsmann Joerg, Kovalszky Ilona, Timar József, Kristiansen Glen, Radzun Heinz-Joachim, Knüchel Ruth, Schuler Martin, Black Peter C, Rübben Herbert, Hadaschik Boris A, Schmid Kurt Werner, van Rhijn Bas W G, Nyirády Péter, Szarvas Tibor
Abstract excerpt
Urachal cancer (UrC) is a rare but aggressive malignancy often diagnosed in advanced stages requiring systemic treatment. Although cytotoxic chemotherapy is of limited effectiveness, prospective clinical studies can hardly be conducted. Targeted therapeutic treatment approaches and potentially immunotherapy based on a biological rationale may provide an alternative strategy. We therefore subjected 70 urachal...
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