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Article

Urachal Carcinoma Shares Genomic Alterations with Colorectal Carcinoma and May Respond to Epidermal Growth Factor Inhibition.

European urology - 1 Nov 2016

Collazo-Lorduy Ana, Castillo-Martin Mireia, Wang Li, Patel Vaibhav, Iyer Gopa, Jordan Emmet, Al-Ahmadie Hikmat, Leonard Issa, Oh William K, Zhu Jun, McBride Russell B, Cordon-Cardo Carlos, Solit David B, Sfakianos John P, Galsky Matthew D

Abstract excerpt

Metastatic urachal carcinoma is a rare, understudied, and aggressive malignancy with limited treatment options. Histologically, urachal carcinomas resemble enteric adenocarcinomas and anecdotally respond to systemic therapies utilized in colorectal cancer. Targeted exome sequencing of archival primary tumor tissue from a patient with metastatic urachal cancer revealed EGFR amplification and wild-type KRAS. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27178450
DOI: 10.1016/j.eururo.2016.04.037
PMCID: PMC5489411

Genes

EGFR
APC
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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