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Article

Optimisation of Tet-On inducible systems for Sleeping Beauty-based chimeric antigen receptor (CAR) applications.

Scientific reports - 4 Aug 2020

Ali Hosseini Rad S M, Poudel Aarati, Tan Grace Min Yi, McLellan Alexander D

Abstract excerpt

Regulated expression of genetic elements that either encode polypeptides or various types of functional RNA is a fundamental goal for gene therapy. Inducible expression may be preferred over constitutive promoters to allow clinician-based control of gene expression. Existing Tet-On systems represent one of the tightest rheostats for control of gene expression in mammals. However, basal expression in absence of...

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Identifiers

PMID: 32753634
DOI: 10.1038/s41598-020-70022-0
PMCID: PMC7403325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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