Endogenous GATA factors bind the core sequence of the tetO and influence gene regulation with the tetracycline system.

Abstract excerpt

The tetracycline-regulated eukaryotic gene expression systems have been applied in numerous areas of bioscience. The systems utilize a tetracycline-responsive promoter (P(tet)) and synthetic transactivators (tTA or rtTA) that bind to the promoter in the presence or absence of doxycycline, regulating gene expression. Both the basal activity of the P(tet) and the magnitude of regulation by the system vary between...

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