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MethylResolver—a method for deconvoluting bulk DNA methylation profiles into known and unknown cell contents

3 Aug 2020

Abstract excerpt

Bulk tissue DNA methylation profiling has been used to examine epigenetic mechanisms and biomarkers of complex diseases such as cancer. However, heterogeneity of cellular content in tissues complicates result interpretation and utility. In silico deconvolution of cellular fractions from bulk tissue data offers a fast and inexpensive alternative to experimentally measuring such fractions. In this study, we report...

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PMID: 32747663
DOI: 10.1038/s42003-020-01146-2

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