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Article

Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data

13 Nov 2017

Abstract excerpt

Immune cells infiltrating tumors can have important impact on tumor progression and response to therapy. We present an efficient algorithm to simultaneously estimate the fraction of cancer and immune cell types from bulk tumor gene expression data. Our method integrates novel gene expression profiles from each major non-malignant cell type found in tumors, renormalization based on cell-type-specific mRNA content,...

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PMID: 29130882
DOI: 10.7554/elife.26476

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