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Performance of tumour microenvironment deconvolution methods in breast cancer using single-cell simulated bulk mixtures

16 Sept 2023

Abstract excerpt

Cells within the tumour microenvironment (TME) can impact tumour development and influence treatment response. Computational approaches have been developed to deconvolve the TME from bulk RNA-seq. Using scRNA-seq profiling from breast tumours we simulate thousands of bulk mixtures, representing tumour purities and cell lineages, to compare the performance of nine TME deconvolution methods (BayesPrism, Scaden,...

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PMID: 37717006
DOI: 10.1038/s41467-023-41385-5

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