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Irc3 is a monomeric DNA branch point-binding helicase in mitochondria of the yeast Saccharomyces cerevisiae.

FEBS letters - 1 Oct 2020

Piljukov Vlad-Julian, Garber Natalja, Sedman Tiina, Sedman Juhan

Abstract excerpt

Irc3 is a superfamily II DNA helicase required for the maintenance of mitochondrial DNA stability in Saccharomyces cerevisiae. Here, we show that recombinant Irc3 is a monomeric protein and that it can form a binary complex with forked DNA. The catalytically active enzyme is a monomer as no positive cooperativity of ATP hydrolysis or DNA unwinding can be detected. Interestingly, we find that Irc3 prefers to...

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PMID: 32735705
DOI: 10.1002/1873-3468.13893

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