Article
The Schizosaccharomyces pombe rfc3+ gene encodes a homologue of the human hRFC36 and Saccharomyces cerevisiae Rfc3 subunits of replication factor C.
Current genetics - 1 Mar 2000
Gray F C, MacNeill S A
Abstract excerpt
In the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe replication factor C (RF-C) plays key roles both in chromosomal DNA replication and in DNA replication checkpoint function. At the replication fork, the five-subunit RF-C complex functions to load the trimeric polymerase accessory factor PCNA onto DNA. PCNA then acts as a sliding clamp, tethering Pol delta to the DNA to maximise its...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Division
- Chromosome Mapping
- DNA Replication
- DNA, Fungal
- DNA-Binding Proteins
- Exons
- Flow Cytometry
- Gene Deletion
- Genes, Fungal
- Genetic Complementation Test
- Homeodomain Proteins
- Humans