Article
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy.
Science (New York, N.Y.) - 25 Sept 2020
Gu Hongjing, Chen Qi, Yang Guan, He Lei, Fan Hang, Deng Yong-Qiang, Wang Yanxiao, Teng Yue, Zhao Zhongpeng, Cui Yujun, Li Yuchang, Li Xiao-Feng, Li Jiangfan, Zhang Na-Na, Yang Xiaolan, Chen Shaolong, Guo Yan, Zhao Guangyu, Wang Xiliang, Luo De-Yan, Wang Hui, Yang Xiao, Li Yan, Han Gencheng, He Yuxian, Zhou Xiaojun, Geng Shusheng, Sheng Xiaoli, Jiang Shibo, Sun Shihui, Qin Cheng-Feng, Zhou Yusen
Abstract excerpt
The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the respiratory tract of aged BALB/c mice. The resulting mouse-adapted strain at passage 6 (called MASCp6) showed increased infectivity in mouse lung and led to...
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