Article
Common and distinct transcriptional signatures of mammalian embryonic lethality.
Nature communications - 26 Jun 2019
Collins John E, White Richard J, Staudt Nicole, Sealy Ian M, Packham Ian, Wali Neha, Tudor Catherine, Mazzeo Cecilia, Green Angela, Siragher Emma, Ryder Edward, White Jacqueline K, Papatheodoru Irene, Tang Amy, Füllgrabe Anja, Billis Konstantinos, Geyer Stefan H, Weninger Wolfgang J, Galli Antonella, Hemberger Myriam, Stemple Derek L, Robertson Elizabeth, Smith James C, Mohun Timothy, Adams David J, Busch-Nentwich Elisabeth M
Abstract excerpt
The Deciphering the Mechanisms of Developmental Disorders programme has analysed the morphological and molecular phenotypes of embryonic and perinatal lethal mouse mutant lines in order to investigate the causes of embryonic lethality. Here we show that individual whole-embryo RNA-seq of 73 mouse mutant lines (>1000 transcriptomes) identifies transcriptional events underlying embryonic lethality and associates...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.