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Article

Enzymatic C-H activation of aromatic compounds through CO2 fixation.

Nature chemical biology - 1 Nov 2020

Aleku Godwin A, Saaret Annica, Bradshaw-Allen Ruth T, Derrington Sasha R, Titchiner Gabriel R, Gostimskaya Irina, Gahloth Deepankar, Parker David A, Hay Sam, Leys David

Abstract excerpt

The direct C-H carboxylation of aromatic compounds is an attractive route to the corresponding carboxylic acids, but remains challenging under mild conditions. It has been proposed that the first step in anaerobic microbial degradation of recalcitrant aromatic compounds is a UbiD-mediated carboxylation. In this study, we use the UbiD enzyme ferulic acid decarboxylase (Fdc) in combination with a carboxylic acid...

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PMID: 32719558
DOI: 10.1038/s41589-020-0603-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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