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Directed evolution of an integral membrane monooxygenase unlocks its full potential.

Bioresource technology - 1 May 2026

Kardashliev Tsvetan, Berlanda Simon F, Schmidt Gregor, Dittrich Petra S, Panke Sven, Held Martin

Abstract excerpt

Chemical synthesis of the API intermediate 2,6-(bis)hydroxymethylpyridine from the natural product lutidine suffers from low atomic efficiency and large consumption of toxic reagents (e.g., potassium permanganate) and solvents. A more sustainable route proceeding at high atom efficiencies and not requiring fossil carbon input during production is catalyzed by recombinant E. coli strains expressing the integral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41724251
DOI: 10.1016/j.biortech.2026.134249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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