Article

An Ehrlich-inspired retrobiosynthesis of pharmaceutical scaffolds

2025-11-11

Abstract excerpt

<h4>ABSTRACT</h4> Brewer’s yeast ( Saccharomyces cerevisiae ) acquires nitrogen from branched-chain and aromatic amino acids via the Ehrlich pathway, generating flavor (fusel) byproducts. Recently, diverting 4-hydroxyphenylacetaldehyde from Ehrlich catabolism of ʟ-tyrosine has enabled microbial production of opioids and other plant benzylisoquinolines. Yet, fusel metabolism is versatile in substrate scope, offer...

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Literature Corpus work: a1df0951-e341-594b-a2ec-36eabf26329d
DOI: 10.1101/2025.11.10.687684

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