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Article

Mycobacterium tuberculosis carrying the rifampicin drug-resistance-conferring rpoB mutation H445Y is associated with suppressed immunity through type I interferons.

mBio - 31 Oct 2023

Bobba Suhas, Howard Nicole C, Das Shibali, Ahmed Mushtaq, Tang Linrui, Thirunavukkarasu Shyamala, Larsen Michelle H, Mathema Barun, Divangahi Maziar, Khader Shabaana A

Abstract excerpt

IMPORTANCE: This study highlights the impact of specific rifampicin-resistance-conferring mutations on the host immune response to Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Clinical reports have previously suggested that multi-drug-resistant) TB patients exhibit altered peripheral immune responses as compared with their drug-sensitive TB counterparts. The murine model of...

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Identifiers

PMID: 37682004
DOI: 10.1128/mbio.00946-23
PMCID: PMC10653897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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