Eicosanoids in the Pancreatic Tumor Microenvironment—A Multicellular, Multifaceted Progression

Abstract excerpt

Background and Aims Eicosanoids, oxidized fatty acids that serve as cell-signaling molecules, have been broadly implicated in tumorigenesis. Here, we aimed to identify eicosanoids associated with pancreatic tumorigenesis and the cell types responsible for their synthesis. Methods We profiled normal pancreas and pancreatic ductal adenocarcinoma in mouse models and patient samples using mass spectrometry. We...

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