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METTL3 polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study.

The journal of gene medicine - 1 Nov 2020

Lin Ao, Zhou Mingming, Hua Rui-Xi, Zhang Jiao, Zhou Haixia, Li Suhong, Cheng Jiwen, Xia Huimin, Fu Wen, He Jing

Abstract excerpt

BACKGROUND: Wilms tumor is a common pediatric tumor worldwide. Methyltransferase like 3 (METTL3) is a core gene of the N6 -methyladenosine (m6 A) modification that widely affects the transcription of tumor-related genes in eukaryotes. METTL3 has been extensively investigated in various tumors but not Wilms tumor. METHODS: We describe a five-center case-control study with 414 patients and 1199 controls aiming to...

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Asian People
Case-Control Studies
China
Infant
Kidney Neoplasms

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Methyltransferases

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PMID: 32716082
DOI: 10.1002/jgm.3255

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