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METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children.

BMC cancer - 4 Dec 2021

Zhuo Zhenjian, Hua Rui-Xi, Zhang Huizhu, Lin Huiran, Fu Wen, Zhu Jinhong, Cheng Jiwen, Zhang Jiao, Li Suhong, Zhou Haixia, Xia Huimin, Liu Guochang, Jia Wei, He Jing

Abstract excerpt

BACKGROUND: Wilms tumor is a highly heritable malignancy. Aberrant METTL14, a critical component of N6-methyladenosine (m6A) methyltransferase, is involved in carcinogenesis. The association between genetic variants in the METTL14 gene and Wilms tumor susceptibility remains to be fully elucidated. We aimed to assess whether variants within this gene are implicated in Wilms tumor susceptibility. METHODS: A total...

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Asian People
Case-Control Studies
Child
Genetic Predisposition to Disease
Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Polymorphism, Single Nucleotide

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Identifiers

PMID: 34863142
DOI: 10.1186/s12885-021-09019-5
PMCID: PMC8643011

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