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Article

ALKBH5 gene polymorphisms and Wilms tumor risk in Chinese children: A five-center case-control study.

Journal of clinical laboratory analysis - 1 Jun 2020

Hua Rui-Xi, Liu Jiabin, Fu Wen, Zhu Jinhong, Zhang Jiao, Cheng Jiwen, Li Suhong, Zhou Haixia, Xia Huimin, He Jing, Zhuo Zhenjian

Abstract excerpt

BACKGROUND: Wilms tumor is a frequently diagnosed renal cancer among children with unclear genetic causes. N6-methyladenosine (m6 A) modification genes play critical roles in tumorigenesis. However, whether genetic variations of m6 A modification genes predispose to Wilms tumor remain unclear. ALKBH5 (AlkB homolog 5), a crucial member of m6 A modification genes, encodes a demethylase that functions to reverse m6...

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Identifiers

PMID: 32091154
DOI: 10.1002/jcla.23251
PMCID: PMC7307367

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