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Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest

30 Mar 2016

Abstract excerpt

Streptococcus pneumoniae produces pneumolysin toxin as a key virulence factor against host cells. Pneumolysin is a cholesterol-dependent cytolysin (CDC) toxin that forms lytic pores in host membranes and mediates pneumococcal disease pathogenesis by modulating inflammatory responses. Here, we show that pneumolysin, which is released during bacterial lysis, induces DNA double strand breaks (DSBs), as indicated by...

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PMID: 27026501
DOI: 10.1038/srep22972

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