Article
Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.
Scientific reports - 25 Sept 2015
Lawrence Sara L, Feil Susanne C, Morton Craig J, Farrand Allison J, Mulhern Terrence D, Gorman Michael A, Wade Kristin R, Tweten Rodney K, Parker Michael W
Abstract excerpt
Pore-forming proteins are weapons often used by bacterial pathogens to breach the membrane barrier of target cells. Despite their critical role in infection important structural aspects of the mechanism of how these proteins assemble into pores remain unknown. Streptococcus pneumoniae is the world's leading cause of pneumonia, meningitis, bacteremia and otitis media. Pneumolysin (PLY) is a major virulence factor...
Topics
- Bacterial Proteins
- Binding Sites
- Carbohydrates
- Crystallography, X-Ray
- Mannose
- Models, Molecular
- Molecular Docking Simulation
- Mutation
- Protein Binding
- Protein Conformation
- Protein Multimerization
- Solutions
- Streptolysins