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Article

Detoxified pneumolysin derivative Plym2 directly protects against pneumococcal infection via induction of inflammatory cytokines.

Immunological investigations - 1 Jan 2014

Lu Jingcai, Sun Tianxu, Hou Hongjia, Xu Man, Gu Tiejun, Dong Yunliang, Wang Dandan, Chen Pinxu, Wu Chunlai, Liang Chunshu, Sun Shiyang, Jiang Chunlai, Kong Wei, Wu Yongge

Abstract excerpt

Streptococcus pneumoniae is a major cause of infectious disease and complications worldwide, such as pneumonia, otitis media, bacteremia and meningitis. New generation protein-based pneumococcal vaccines are recognized as alternative vaccine candidates. Pneumolysin (Ply) is a cholesterol-dependent cytolysin produced by all clinical isolates of S. pneumoniae. Our research group previously developed a highly...

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Identifiers

PMID: 25020076
DOI: 10.3109/08820139.2014.930478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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