Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The predictability of molecular evolution during functional innovation.

Proceedings of the National Academy of Sciences of the United States of America - 25 Feb 2014

Blank Diana, Wolf Luise, Ackermann Martin, Silander Olin K

Abstract excerpt

Determining the molecular changes that give rise to functional innovations is a major unresolved problem in biology. The paucity of examples has served as a significant hindrance in furthering our understanding of this process. Here we used experimental evolution with the bacterium Escherichia coli to quantify the molecular changes underlying functional innovation in 68 independent instances ranging over 22...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Biological
Share to Directed Molecular Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Intergenic

Share to Escherichia coli

Share to Evolution, Molecular

Share to Genetics, Population

Share to Metabolic Networks and Pathways

Share to Population Density

Source

Open in PubMed Open full text

Identifiers

PMID: 24516157
DOI: 10.1073/pnas.1318797111
PMCID: PMC3939917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The predictability of molecular evolution during functional innovation.PMID 24516157Read ↗

The molecular origins of evolutionary innovations.Semantic proximity Read ↗

Functional innovation through new genes as a general evolutionary process.Semantic proximity Read ↗

Information theory, evolutionary innovations and evolvability.Semantic proximity Read ↗

The Genomic Basis of Evolutionary Innovation in Pseudomonas aeruginosa.Semantic proximity Read ↗

Experimental Evolution Reveals Unifying Systems-Level Adaptations but Diversity in Driving Genotypes.Semantic proximity Read ↗

Use of adaptive laboratory evolution to discover key mutations enabling rapid growth of Escherichia coli K-12 MG1655 on glucose minimal medium.Semantic proximity Read ↗

The landscape of transcriptional and translational changes over 22 years of bacterial adaptation.Semantic proximity Read ↗

Evolutionary dynamics and structural consequences of de novo beneficial mutations and mutant lineages arising in a constant environment.Semantic proximity Read ↗

Building synthetic systems to learn nature's design principles.Semantic proximity Read ↗

Robustness and innovation in synthetic genotype networks.Semantic proximity Read ↗

Predicting the evolution of Escherichia coli by a data-driven approach.Semantic proximity Read ↗

Causal mutations from adaptive laboratory evolution are outlined by multiple scales of genome annotations and condition-specificity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.