Article
Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants.
Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2020
Crouch Daniel J M, Bodmer Walter F
Abstract excerpt
The reconciliation between Mendelian inheritance of discrete traits and the genetically based correlation between relatives for quantitative traits was Fisher's infinitesimal model of a large number of genetic variants, each with very small effects, whose causal effects could not be individually identified. The development of genome-wide genetic association studies (GWAS) raised the hope that it would be possible...
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