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Article

The evolutionary trajectories of P. aeruginosa in biofilm and planktonic growth modes exposed to ciprofloxacin: beyond selection of antibiotic resistance.

NPJ biofilms and microbiomes - 24 Jul 2020

Ahmed Marwa N, Abdelsamad Ahmed, Wassermann Tina, Porse Andreas, Becker Janna, Sommer Morten O A, Høiby Niels, Ciofu Oana

Abstract excerpt

Ciprofloxacin (CIP) is used to treat Pseudomonas aeruginosa biofilm infections. We showed that the pathways of CIP-resistance development during exposure of biofilms and planktonic P. aeruginosa populations to subinhibitory levels of CIP depend on the mode of growth. In the present study, we analyzed CIP-resistant isolates obtained from previous evolution experiments, and we report a variety of evolved phenotypic...

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PMID: 32709907
DOI: 10.1038/s41522-020-00138-8
PMCID: PMC7381665

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