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Article

Sublethal ciprofloxacin treatment leads to rapid development of high-level ciprofloxacin resistance during long-term experimental evolution of Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Sept 2013

Jørgensen Karin Meinike, Wassermann Tina, Jensen Peter Østrup, Hengzuang Wang, Molin Søren, Høiby Niels, Ciofu Oana

Abstract excerpt

The dynamics of occurrence and the genetic basis of ciprofloxacin resistance were studied in a long-term evolution experiment (940 generations) in wild-type, reference strain (PAO1) and hypermutable (PAOΔmutS and PAOMY-Mgm) P. aeruginosa populations continuously exposed to sub-MICs (1/4) of ciprofloxacin. A rapid occurrence of ciprofloxacin-resistant mutants (MIC of ≥12 μg/ml, representing 100 times the MIC of...

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Identifiers

PMID: 23774442
DOI: 10.1128/AAC.00493-13
PMCID: PMC3754285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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