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Article

Evolutionary adaptations of Pseudomonas aeruginosa biofilms to ciprofloxacin and antioxidant co-treatment in synthetic sputum medium.

Microbiology spectrum - 3 Mar 2026

Higazy Doaa, Vergauwe Fauve, Coenye Tom, Ciofu Oana

Abstract excerpt

Antimicrobial resistance (AMR) is a growing public health concern, particularly in biofilm-related infections, where microbial aggregates display high levels of tolerance. Oxidative stress has been hypothesized to accelerate the development of resistance, whereas antioxidants (AOs) may mitigate this process. In this study, we investigated the impact of AOs on the evolution of ciprofloxacin (CIP) resistance in...

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Identifiers

PMID: 41677304
DOI: 10.1128/spectrum.03149-25
PMCID: PMC12955469

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