Article
Evolution of Antibiotic Resistance in Biofilm and Planktonic Pseudomonas aeruginosa Populations Exposed to Subinhibitory Levels of Ciprofloxacin.
Antimicrobial agents and chemotherapy - 1 Aug 2018
Ahmed Marwa N, Porse Andreas, Sommer Morten Otto Alexander, Høiby Niels, Ciofu Oana
Abstract excerpt
The opportunistic Gram-negative pathogen Pseudomonas aeruginosa, known for its intrinsic and acquired antibiotic resistance, has a notorious ability to form biofilms, which often facilitate chronic infections. The evolutionary paths to antibiotic resistance have mainly been investigated in planktonic cultures and are less studied in biofilms. We experimentally evolved P. aeruginosa PAO1 colony biofilms and...
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