Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ralaniten Sensitizes Enzalutamide-Resistant Prostate Cancer to Ionizing Radiation in Prostate Cancer Cells that Express Androgen Receptor Splice Variants

21 Jul 2020

Abstract excerpt

Blocking androgen receptor (AR) transcriptional activity by androgen deprivation therapy (ADT) improves the response to radiotherapy for intermediate and high risk prostate cancer. Unfortunately, ADT, antiandrogens, and abiraterone increase expression of constitutively active splice variants of AR (AR-Vs) which regulate DNA damage repair leading to resistance to radiotherapy. Here we investigate whether blocking...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Lipids, and Metabolism
Share to Prostate Cancer Diagnosis and Treatment
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32708219
DOI: 10.3390/cancers12071991

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ralaniten Sensitizes Enzalutamide-Resistant Prostate Cancer to Ionizing Radiation in Prostate Cancer Cells that Express Androgen Receptor Splice VariantsPMID 32708219Read ↗

Novel hormone therapies for advanced prostate cancer: Understanding and countering drug resistanceSemantic proximity Read ↗

Targeting androgen receptor-independent pathways in therapy-resistant prostate cancerSemantic proximity Read ↗

Radiosensitization by enzalutamide for human prostate cancer is mediated through the DNA damage repair pathwaySemantic proximity Read ↗

The Androgen Receptor Does Not Directly Regulate the Transcription of DNA Damage Response GenesSemantic proximity Read ↗

The androgen receptor does not directly regulate the transcription of DNA damage response genesSemantic proximity Read ↗

The interconnection between androgen receptor and DNA damage response pathways in prostate cancerSemantic proximity Read ↗

Sensitization of prostate cancer to radiation therapy: Molecules and pathways to target.Semantic proximity Read ↗

Androgen receptor contributes to radioresistance through DNA repair and autophagy in AR-positive prostate cancer cellsSemantic proximity Read ↗

Epigenetic mechanisms underlying prostate cancer radioresistanceSemantic proximity Read ↗

Androgen Receptor Variants Mediate DNA Repair after Prostate Cancer IrradiationSemantic proximity Read ↗

Castration-resistant prostate cancer: Androgen receptor inactivation induces telomere DNA damage, and damage response inhibition leads to cell deathSemantic proximity Read ↗

Targeted Radiosensitization of ETS Fusion-Positive Prostate Cancer through PARP1 InhibitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.