Article

Androgen receptor contributes to radioresistance through DNA repair and autophagy in AR-positive prostate cancer cells

2025-12-05

Abstract excerpt

Androgen receptor (AR) is a critical therapeutic target in prostate cancer (PCa), and androgen blockade is known to act synergistically with radiation therapy. However, the mechanisms through which AR modulates radiation response are not yet fully understood. In this study, we aimed to investigate the role of AR in mediating radioresistance in PCa. AR-positive LNCaP and castration-resistant C4-2 cells exhibited si...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 066044a7-f6bd-5ca5-9617-00d1f0607dff
DOI: 10.64898/2025.12.03.690226

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Androgen receptor contributes to radioresistance through DNA repair and autophagy in AR-positive prostate cancer cellsDOI 10.64898/2025.12.03.690226Read

Uncovering the Secrets of Prostate Cancer’s Radiotherapy Resistance: Advances in Mechanism ResearchSemantic proximity Read

Sensitization of prostate cancer to radiation therapy: Molecules and pathways to target.Semantic proximity Read

PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathwaysSemantic proximity Read

The interconnection between androgen receptor and DNA damage response pathways in prostate cancerSemantic proximity Read

Androgen Receptor Variants Mediate DNA Repair after Prostate Cancer IrradiationSemantic proximity Read

DAB2IP Regulates Autophagy in Prostate Cancer in Response to Combined Treatment of Radiation and a DNA-PKcs InhibitorSemantic proximity Read

RNA-seq profiling of a radiation resistant and radiation sensitive prostate cancer cell line highlights opposing regulation of DNA repair and targets for radiosensitizationSemantic proximity Read

PARP Inhibition Sensitizes to Low Dose-Rate Radiation TMPRSS2-ERG Fusion Gene-Expressing and PTEN-Deficient Prostate Cancer CellsSemantic proximity Read

Targeting androgen receptor-independent pathways in therapy-resistant prostate cancerSemantic proximity Read

Radiosensitization by enzalutamide for human prostate cancer is mediated through the DNA damage repair pathwaySemantic proximity Read

Targeted Radiosensitization of ETS Fusion-Positive Prostate Cancer through PARP1 InhibitionSemantic proximity Read

Epigenetic mechanisms underlying prostate cancer radioresistanceSemantic proximity Read