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Article

Targeted Radiosensitization of ETS Fusion-Positive Prostate Cancer through PARP1 Inhibition

1 Oct 2013

Abstract excerpt

ETS gene fusions, which result in overexpression of an ETS transcription factor, are considered driving mutations in approximately half of all prostate cancers. Dysregulation of ETS transcription factors is also known to exist in Ewing's sarcoma, breast cancer, and acute lymphoblastic leukemia. We previously discovered that ERG, the predominant ETS family member in prostate cancer, interacts with the DNA damage...

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PMID: 24204199
DOI: 10.1593/neo.131604

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