Glutathione peroxidase 4 inhibits Wnt/β-catenin signaling and regulates dorsal organizer formation in zebrafish embryos.

doi:10.1242/dev.144261

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Article

Glutathione peroxidase 4 inhibits Wnt/β-catenin signaling and regulates dorsal organizer formation in zebrafish embryos.

Development (Cambridge, England) - 1 May 2017

Rong Xiaozhi, Zhou Yumei, Liu Yunzhang, Zhao Beibei, Wang Bo, Wang Caixia, Gong Xiaoxia, Tang Peipei, Lu Ling, Li Yun, Zhao Chengtian, Zhou Jianfeng

Abstract excerpt

The Wnt/β-catenin signaling pathway plays pivotal roles in axis formation during embryogenesis and in adult tissue homeostasis. Glutathione peroxidase 4 (GPX4) is a selenoenzyme and participates in the reduction of peroxides. Its synthesis depends on the availability of the element selenium. However, the roles of GPX4 in vertebrate embryonic development and underlying mechanisms are largely unknown. Here, we show...

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PMID: 28302747
DOI: 10.1242/dev.144261
PMCID: PMC6514413

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GPX4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.