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Mutational spectrum and risk stratification of intermediate-risk acute myeloid leukemia patients based on next-generation sequencing.

Oncotarget - 31 May 2016

Wang Bianhong, Liu Yangyang, Hou Guangyuan, Wang Lili, Lv Na, Xu Yuanyuan, Xu Yihan, Wang Xiuli, Xuan Zhaoling, Jing Yu, Li Honghua, Jin Xiangshu, Deng Ailing, Wang Li, Gao Xiaoning, Dou Liping, Liang Junbin, Chen Chongjian, Li Yonghui, Yu Li

Abstract excerpt

Intermediate-risk acute myeloid leukemia (IR-AML), which accounts for a substantial number of AML cases, is highly heterogeneous. Although several mutations have been identified, the heterogeneity of AML is uncertain because novel mutations have yet to be discovered. Here we applied next generation sequencing (NGS) platform to screen mutational hotspots in 410 genes relevant to hematological malignancy. IR-AML...

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Identifiers

PMID: 27062340
DOI: 10.18632/oncotarget.7028
PMCID: PMC5077997

Genes

FLT3
NPM1
IDH2
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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