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Article

Mucins and Truncated O-Glycans Unveil Phenotypic Discrepancies between Serous Ovarian Cancer Cell Lines and Primary Tumours.

International journal of molecular sciences - 13 Jul 2018

Coelho Ricardo, Marcos-Silva Lara, Mendes Nuno, Pereira Daniela, Brito Catarina, Jacob Francis, Steentoft Catharina, Mandel Ulla, Clausen Henrik, David Leonor, Ricardo Sara

Abstract excerpt

Optimal research results rely on the selection of cellular models capable of recapitulating the characteristics of primary tumours from which they originate. The expression of mucins (MUC16 and MUC1) and truncated O-glycans (Tn, STn and T) represents a characteristic footprint of serous ovarian carcinomas (SOCs). Therefore, selecting ovarian cancer (OVCA) cell lines that reflect this phenotype is crucial to...

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Source

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Identifiers

PMID: 30011875
DOI: 10.3390/ijms19072045
PMCID: PMC6073732

Genes

MUC1
MUC16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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