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Cosmc transfection decreases malignant behavior of Tn+ cells and enhances sensitivity to apoptosis when induced by Apo2L/TRAIL via alteration of O-glycan structure.

Aging - 13 Oct 2021

Ding Ruisong, Hu Xingyou, Hu Wen, Du Zhenzhen, Huang Panpan, Wang Mengyang, Sheng Jiaoyue, Ma Yanchao, Wang Ailing, Luan Xiying, Dong Menghua, Cao Qizhi, Zou Yanfen, Hu Tao

Abstract excerpt

Cosmc mutations may cause abnormal O-glycosylation and result in Tn antigen expression. In the current study, it was discovered that proliferation and migration of Tn+ cells (Jurkat T and LS174T-Tn+ cells) with mutant Cosmc decreased after transfected Cosmc, and their sensitivity to apoptosis induced by Apo2L/TRAIL increased. Core 1-, 2-, and 3-derived O-glycans were absent in Tn+ cells. After Cosmc transfection,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34644263
DOI: 10.18632/aging.203633
PMCID: PMC8549606

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