Article

Core Fucosylation Mediated by the FucT-8 Enzyme Affects Trail-Induced Apoptosis and Sensitivity to Chemotherapy in Human SW480 and SW620 Colorectal Cancer Cells

2023-06-30

Abstract excerpt

Epithelial cells can undergo apoptosis by manipulating the balance between pro-survival and apoptotic signals. In this work, we show that TRAIL-induced apoptosis can be differentially regulated by the expression of α(1,6)fucosyltransferase (FucT-8), the only enzyme in mammals that transfers the (1,6)fucose residue to the pentasaccharide core of complex N-glycans. Specifically, in the cellular model of colorectal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f607674-6b74-5ca4-b8e0-7a7e24c75327
DOI: 10.20944/preprints202306.2147.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Core Fucosylation Mediated by the FucT-8 Enzyme Affects Trail-Induced Apoptosis and Sensitivity to Chemotherapy in Human SW480 and SW620 Colorectal Cancer CellsDOI 10.20944/preprints202306.2147.v1Read

FUT8-mediated core fucosylation modulates growth-related functions of LRP1 in liver cancer cellsSemantic proximity Read

FUT2-dependent fucosylation of LAMP1 promotes the apoptosis of colorectal cancer cells by regulating the autophagy-lysosomal pathwaySemantic proximity Read

Terminal fucose mediates progression of human cholangiocarcinoma through EGF/EGFR activation and the Akt/Erk signaling pathwaySemantic proximity Read

Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancerSemantic proximity Read

O-glycans on death receptors in cells modulate their sensitivity to TRAIL-induced apoptosis through affecting on their stability and oligomerization.Semantic proximity Read

Low-Molecular-Weight Fucoidan as Complementary Therapy of Fluoropyrimidine-Based Chemotherapy in Colorectal CancerSemantic proximity Read

Loss of α1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling.Semantic proximity Read

MAP kinase ERK5 modulates cancer cell sensitivity to extrinsic apoptosis induced by death-receptor agonists and Natural Killer cellsSemantic proximity Read

Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling.Semantic proximity Read

Widespread multi-targeted therapy resistance via drug-induced secretome fucosylationSemantic proximity Read

O-GlcNAcylation inhibition redirects the response of colon cancer cells to chemotherapy from senescence to apoptosisSemantic proximity Read

EGFR core fucosylation, induced by enveloped viruses, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defensesSemantic proximity Read