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Article

BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency

20 Jul 2020

Abstract excerpt

contribute to lung cancer progression. Using a combination of gain- and loss-of-function approaches, we demonstrate that deletion of BRG1 in lung cancer leads to activation of replication stress responses. Single-molecule assessment of replication fork dynamics in BRG1-deficient cells revealed increased origin firing mediated by the prelicensing protein, CDC6. Quantitative mass spectrometry and...

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PMID: 32690724
DOI: 10.1158/0008-5472.can-20-1744

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