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Article

Fentanyl pharmacokinetics is not dependent on hepatic uptake by organic anion-transporting polypeptide 1B1 in human beings.

Basic & clinical pharmacology & toxicology - 1 Jul 2013

Ziesenitz Victoria C, König Sonja K, Mahlke Nina, Jantos Ricarda, Skopp Gisela, Weiss Johanna, Haefeli Walter E, Mikus Gerd

Abstract excerpt

A recent study investigating the pharmacokinetics of fentanyl in Sprague-Dawley rats suggested fentanyl to be a substrate of rat organic anion-transporting polypeptide Oatp. In human beings, the most important OATP for the pharmacokinetics of many drugs is OATP1B1. Therefore, genetic variants of OATP1B1 (SLCO1B1) might modulate fentanyl pharmacokinetics and efficacy in human beings. Sixteen healthy male and...

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Identifiers

PMID: 23480028
DOI: 10.1111/bcpt.12066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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