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Article

Relationship among genetic polymorphism of SLCO1B1, rifampicin exposure and clinical outcomes in patients with active pulmonary tuberculosis.

British journal of clinical pharmacology - 1 Sept 2021

Kim Eun Sun, Kwon Byoung Soo, Park Jong Sun, Chung Jae-Yong, Seo Soo Hyun, Park Kyoung Un, Song Junghan, Yoon Seonghae, Lee Jae Ho

Abstract excerpt

AIMS: Rifampicin is a key drug for the treatment of tuberculosis (TB). Little is known for the relationship between the rifampicin pharmacokinetics and genetic polymorphisms in the Asian population. We aimed to investigate relationship between genetic polymorphism of SLCO1B1 and rifampicin exposure and its impact on clinical outcomes in Korean patients with active pulmonary TB. METHODS: From February 2016 to...

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PMID: 33538008
DOI: 10.1111/bcp.14758

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