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Article

The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: dosing implications.

Antimicrobial agents and chemotherapy - 1 Sept 2011

Chigutsa Emmanuel, Visser Marianne E, Swart Elizabeth C, Denti Paolo, Pushpakom Sudeep, Egan Deirdre, Holford Nicholas H G, Smith Peter J, Maartens Gary, Owen Andrew, McIlleron Helen

Abstract excerpt

Among patients with tuberculosis, rifampin plasma concentrations and sputum conversion rates have been reported to be lower in Africans. Rifampin is a substrate of P-glycoprotein (coded for by the ABCB1 gene) and organic anion-transporting polypeptide 1B1 (coded for by SLCO1B1). The objectives were to identify genetic polymorphisms of drug transporters and the transcriptional regulators pregnane X receptor (PXR)...

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Share to Antibiotics, Antitubercular
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Constitutive Androstane Receptor

Share to Liver-Specific Organic Anion Transporter 1

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Share to Pregnane X Receptor

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Source

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Identifiers

PMID: 21709081
DOI: 10.1128/AAC.01833-10
PMCID: PMC3165308

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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