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Article

Unexpected lack of effect of the rifampin-induced P-glycoprotein on the oral bioavailability of its substrate, talinolol, in humans: implication in phenotyping.

Journal of pharmaceutical sciences - 1 Jan 2003

Chiou Win L, Ma Chien, Wu Ta-Chen, Jeong Hyun Young

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Share to Administration, Oral
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Biological Availability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Propanolamines

Share to Rifampin

Share to Stereoisomerism

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Source

Identifiers

PMID: 12486675
DOI: 10.1002/jps.10261

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unexpected lack of effect of the rifampin-induced P-glycoprotein on the oral bioavailability of its substrate, talinolol, in humans: implication in phenotyping.PMID 12486675Read ↗

Insights into Intestinal P-glycoprotein Function using Talinolol: A PBPK Modeling ApproachSemantic proximity Read ↗

Influence of genetic polymorphisms on intestinal expression and rifampicin-type induction of ABCC2 and on bioavailability of talinolol.Semantic proximity Read ↗

Rifampicin reduces plasma concentrations of celiprolol.Semantic proximity Read ↗

Importance of P‐glycoprotein for drug disposition in humansSemantic proximity Read ↗

Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptorSemantic proximity Read ↗

Induction of intestinal P-glycoprotein by St John's wort reduces the oral bioavailability of talinolol.Semantic proximity Read ↗

Transporter and metabolizer gene polymorphisms affect fluoroquinolone pharmacokinetic parametersSemantic proximity Read ↗

Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation.Semantic proximity Read ↗

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters.Semantic proximity Read ↗

No sex difference in overall P-glycoprotein activity as assessed by talinolol disposition in humans.Semantic proximity Read ↗

Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human HepatocytesSemantic proximity Read ↗

Disposition and sterol-lowering effect of ezetimibe are influenced by single-dose coadministration of rifampin, an inhibitor of multidrug transport proteins.Semantic proximity Read ↗

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