Article
Mice Hypomorphic for Keap1, a Negative Regulator of the Nrf2 Antioxidant Response, Show Age-Dependent Diffuse Goiter with Elevated Thyrotropin Levels.
Thyroid : official journal of the American Thyroid Association - 1 Jan 2021
Ziros Panos G, Renaud Cédric O, Chartoumpekis Dionysios V, Bongiovanni Massimo, Habeos Ioannis G, Liao Xiao-Hui, Refetoff Samuel, Kopp Peter A, Brix Klaudia, Sykiotis Gerasimos P
Abstract excerpt
Background: Familial nontoxic multinodular goiter (MNG) is a rare disease. One of the associated genes is Kelch-like ECH-associated protein 1 (KEAP1), which encodes the main inhibitor of nuclear factor erythroid 2-related transcription factor 2 (Nrf2), a central mediator of antioxidant responses. The association of KEAP1 with familial MNG is based on only two loss-of-function mutations identified in two families,...
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