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Article

Genetic analysis of cytoprotective functions supported by graded expression of Keap1.

Molecular and cellular biology - 1 Jun 2010

Taguchi Keiko, Maher Jonathan M, Suzuki Takafumi, Kawatani Yukie, Motohashi Hozumi, Yamamoto Masayuki

Abstract excerpt

Keap1 regulates Nrf2 activity in response to xenobiotic and oxidative stresses. Nrf2 is an essential regulator of cytoprotective genes. Keap1-null mice are lethal by weaning age due to malnutrition caused by severe hyperkeratosis of the upper digestive tract. Analysis of Keap1::Nrf2 double mutant mice revealed that currently recognizable phenotypes of Keap1-null mice are all attributable to constitutive...

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Identifiers

PMID: 20404090
DOI: 10.1128/MCB.01591-09
PMCID: PMC2876677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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