Article
Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells.
Disease models & mechanisms - 1 Mar 2014
Kong Xiang Y, Nesset Cecilie Kasi, Damme Markus, Løberg Else-Marit, Lübke Torben, Mæhlen Jan, Andersson Kristin B, Lorenzo Petra I, Roos Norbert, Thoresen G Hege, Rustan Arild C, Kase Eili T, Eskild Winnie
Abstract excerpt
Human kidney predominant protein, NCU-G1, is a highly conserved protein with an unknown biological function. Initially described as a nuclear protein, it was later shown to be a bona fide lysosomal integral membrane protein. To gain insight into the physiological function of NCU-G1, mice with no detectable expression of this gene were created using a gene-trap strategy, and Ncu-g1(gt/gt) mice were successfully...
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